Chromosome segregation
Chromosome segregation - We are studying the process of chromosome segregation in eukaryotic cells. Accurate chromosome segregation is critical to ensure that cells are duplicated without genome loss or damage. Chromosome segregation mechanisms are conserved from yeast cells to humans. Chromosomes are replicated during S-phase and are then segregated by a microtubule spindle during mitosis.
We are interested in understanding how the chromosomes attach to the microtubule spindle during mitosis so that each daughter cell receives one and only one of each sister chromatid. We study how the forces for chromosome segregation are generated within the mitotic spindle and along the length of the chromosome and the mechanisms cells use to detect and correct errors during mitosis.
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